In President Obama’s final State of the Union address, he defined American leadership as “rallying the world behind causes that are right.” The global health goals of ending malaria and HIV/AIDS are no longer deemed too ambitious or too complex. And that’s because we’ve done it before. The story of U.S. leadership in the fight against infectious diseases is one of immense success and progress. From smallpox, measles, Guinea worm and polio, to malaria and Ebola, our determination, grit and know-how have helped eliminate or push many killers to the brink of extinction.

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